DOSE-RESPONSE RELATIONSHIP FOR INHALED NITRIC OXIDE IN EXPERIMENTAL PULMONARY HYPERTENSION IN SHEEP
نویسندگان
چکیده
منابع مشابه
Dose-response relationship for inhaled nitric oxide in experimental pulmonary hypertension in sheep.
We have examined the effect of inhaled nitric oxide 4-512 p.p.m. in six sheep with pulmonary hypertension induced first with hypoxia and then with 6 micrograms kg-1 of E. coli endotoxin. A similar dose-dependent reduction in pulmonary artery pressure occurred in pulmonary hypertension induced by hypoxia or endotoxin, with a maximum effect of 25-30% decrease with nitric oxide 64 p.p.m. Increasin...
متن کاملInhaled nitric oxide in persistent pulmonary hypertension of the newborn.
Nitric oxide (NO) has vasodilatory effects on the pulmonary vasculature in adults and animals. We examined the effects on systemic oxygenation and blood pressure of inhaling up to 80 parts per million by volume of NO at FiO2 0.9 for up to 30 minutes by 6 infants with persistent pulmonary hypertension of the newborn (PPHN). In all infants this treatment rapidly and significantly increased preduc...
متن کاملPulmonary Hypertension in Neonates: Inhaled Nitric Oxide vs Epoprostenol (Flolan)
J Lung Pulm Respir Res 2016, 3(3): 00082 selectively targets pulmonary vessels, causing a potent and sustained vasodilatation, and therefore increasing pulmonary blood flow [2]. After diffusion across the alveolar capillary membrane, the iNO is absorbed by subjacent smooth muscles of the pulmonary vasculature to activate soluble guanylate cyclase, which is responsible for conversion of GTP to c...
متن کاملOne-year continuous inhaled nitric oxide for primary pulmonary hypertension.
We describe a case of long-term administration of nitric oxide (NO) in a 32-year-old man who was admitted with exertional dyspnea and anasarca. A diagnosis of primary pulmonary hypertension was made. An acute vasodilator trial with inhaled NO showed a 5% reduction of the mean pulmonary artery pressure. Long-term NO inhalation therapy was initiated. Twenty days later, the dyspnea improved, the a...
متن کاملCombined inhaled nitric oxide and inhaled prostacyclin during experimental chronic pulmonary hypertension.
Inhaled nitric oxide (NO) and inhaled prostacyclin (PGI2) produce selective reductions in pulmonary vascular resistance (PVR) through differing mechanisms. NO decreases PVR via cGMP, and PGI2 produces pulmonary vasodilation via cAMP. As a general pharmacological principle, two drugs that produce similar effects via different mechanisms should have additive or synergistic effects when combined. ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1993
ISSN: 0007-0912
DOI: 10.1093/bja/71.5.702